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"Denny Island (Welsh: Ynys Denny) () is a small rocky island of , with scrub vegetation, in the Severn Estuary. Its rocky southern foreshore marks the boundary between England and Wales. Above high water mark, the island is reckoned administratively to Monmouthshire, South Wales. The island also marks the north-western limit of the City of Bristol's water boundary in the Severn estuary. It is located approximately three miles north of Portishead, midway between Redwick in Wales and Avonmouth in England. It is surrounded by sandbanks known as the Welsh Grounds. Its foreshore area changes dramatically according to the state of the tide, because tides in the estuary and Bristol Channel are amongst the highest in the world, reaching at the spring equinox. It is known as a nesting-place for gulls, cormorants and other seabirds, which are regularly seen and ringed there. History Denny Island appears in the historical record for the first time as Dunye, in the charter recording the creation of the county of Bristol in 1373. This suggests that the name means, in Old English, 'island shaped like a down (i.e. a hill with a rounded profile)'. It gives its name to the Denny Island Fault Zone, a part of the Avon-Solent Fracture zone. In 2004, the island was subject to an unsuccessful appeal under Section 6(1) of the Countryside and Rights of Way Act 2000 against it appearing on a map of registered common land. References External links *Images of Denny Island from www.geograph.co.uk Category:Islands of the Bristol Channel Category:Uninhabited islands of Wales Category:Islands of Monmouthshire Category:Islands of the River Severn Category:River islands of Wales "
"Brad or Bradley Smith may refer to: Sportspeople *Bradley Smith (cricketer) (born 1969), English former cricketer *Brad Smith (footballer, born 1948), Australian rules footballer and premiership coach of East Fremantle *Brad Smith (ice hockey) (born 1958), Canadian ice hockey player *Brad Smith (soccer) (born 1965), American soccer player *Brad Smith (racing driver) (born 1968), American stock car racing driver *Brad Smith (footballer, born 1977), Australian rules footballer, ruckman from Claremont *Brad Smith (footballer, born 1979), Australian rules footballer for Subiaco *Brad Smith (American football) (born 1983), American football player *Brad Smith (Canadian football) (born 1983), Canadian footballer *Bradley Smith (motorcyclist) (born 1990), British motorcyclist *Bradley Smith (racing driver) (born 1991), British racing driver *Brad Smith (footballer, born 1994), Australian international footballer for A.F.C. Bournemouth *Brad Smith (Scottish footballer) (born 1997), Scottish footballer for Dundee United F.C. Other people *Bradley Smith (photographer) (1910–1997), American magazine photographer, writer, and photojournalist *Bradley Smith (Holocaust denier) (1930–2016) *Bradley Smith (law professor) (born 1958), political scientist and former Federal Election Commission chairman *Brad Smith (American lawyer) (born 1959), president and chief legal officer of Microsoft *Brad Smith (entrepreneur) (born 1987), Australian entrepreneur, founder of braaap *Brad D. Smith, American executive with Intuit, Inc. *Bradley R. Smith (born 1985), Graphic Designer and owner of bluebrad.com See also *Brad Smyth (born 1973), Canadian ice hockey player *Braydon Smith (1991–2015), nicknamed Brayd, Australian boxer "
"George McDonald Church (born 28 August 1954) is an American geneticist, molecular engineer, and chemist. He is the Robert Winthrop Professor of Genetics at Harvard Medical School, Professor of Health Sciences and Technology at Harvard and MIT, and a founding member of the Wyss Institute for Biologically Inspired Engineering. As of March 2017, Church serves as a member of the Bulletin of the Atomic Scientists' Board of Sponsors. Education and early life George McDonald Church was born on 28 August 1954 on MacDill Air Force Base near Tampa, Florida, and grew up in nearby Clearwater;David Ewing Duncan, 2010, "On a Mission to Sequence the Genomes of 100,000 People: The geneticist George Church advises or licenses technology to most companies involved in sequencing, The New York Times, 7 June 2010, see . Retrieved 26 February 2015. he attended high school at the preparatory boarding school Phillips Academy, in Andover, Massachusetts, from 1968 to 1972.Alex Salton, 2009, "Geneticist George Church '72 Sought Independence at PA," The Phillipian, 17 April 2009, see . Retrieved 2 March 2015. He then studied at Duke University, completing a bachelor's degree in zoology and chemistry in two years. In the fall of 1973, Church began research work at Duke University with assistant professor of biochemistry Sung-Hou Kim, work that continued a year later with Church in a graduate biochemistry program at Duke on an NSF fellowship. As Peter Miller reported for the National Geographic series, "The Innovators": > "As a graduate student at Duke… he used x-ray crystallography to study the > three-dimensional structure of "transfer" RNA, which decodes DNA and carries > instructions to other parts of the cell. It was groundbreaking research, but > Church spent so much time in the lab—up to a hundred hours a week—that he > neglected his other classes [in the fall of 1975]".Peter Miller, 2015, > "News, The Innovators Project: George Church, The Future Without Limits," > National Geographic (online), see . Retrieved 26 February 2015. As a result, Church was not compliant with Duke graduate academic policies, and was withdrawn from the degree program in January 1976. He was told that "[We] hope that whatever problems… contributed to your lack of success… at Duke will not keep you from a successful pursuit of a productive career."Duke University Graduate School, Office of the Dean, 1976, "Dear Mr. Church…", 16 January 1976, private letter from W.G. Katzenmeyer, Associate Dean, to George McDonald Church, in the archives of G.M. Church, see . Retrieved 4 March 2015. The work gave rise to publications that include a Proceedings report with Church as lead author on an early model for molecular interactions between the minor groove of double-stranded DNA and β-ribbons of proteins.G. M. Church, J. L. Sussman & S.-H. Kim, 1977, "Secondary structural complementarity between DNA and proteins," Proc. natn. Acad. Sci. U.S.A. 74:1458–1462, see . Retrieved 4 March 2015.Commenting on the new Wayne F. Anderson, Brian Matthews, et al. structure of a Cro repressor-DNA complex, and on the new David B. McKay and Thomas Steitz structure of a CAP-cAMP complex; David Davies, 1981, "Two DNA- binding proteins," Nature 290:736f, see . Retrieved 4 March 2015. Church returned to graduate work at Harvard University in 1977 under Walter Gilbert,Jeffrey Perkel, 2013, "BioTechniques: Celebrating 30 Years of Methods Development," BioTechniques 55(5), November 2013, 227–230, see . Retrieved 21 March 2014. and completed a PhD in biochemistry and molecular biology working on mobile genetic elements within introns of yeast mitochondrial and mouse Immunoglobulin genes (1984). Career After completing his doctoral work, Church spent six months of 1984 at Biogen, the industrial laboratory site where Prof. Gilbert had relocated a sizable part of his former Harvard group; this was followed soon after by a Life Sciences Research Foundation postdoctoral fellowship at the University of California, San Francisco with Gail R. Martin,LSRF, 2015, "Resources, 1983 Fellow George Church," see . Retrieved 26 February 2015.LSRF, 2015, "Fellows:Alumni, George Church (1984)," see . Retrieved 26 February 2015. a member of the National Academy of Sciences and joint-discoverer of a technique to extract mouse embryonic stem cells.Elie Dolgin, 2009, "Stem cell rat race," in The Scientist (magazine), 1 April 2009, see . Retrieved 26 February 2015. Church joined the Harvard Medical School faculty as an assistant professor in 1986. Church is now the Robert Winthrop Professor of Genetics at Harvard Medical School,Heidi Legg, 2014, "Harvard Professor George Church and the future of genomics," at BetaBoston, a Boston Globe site (online), 25 December 2014, see . Retrieved 2 March 2015. and a member of the Harvard-MIT health sciences and technology faculty. H was also a founding member of the Wyss Institute for Biologically Inspired Engineering at Harvard University. Church has also served as director of the Center on Bioenergy Technology at Harvard, funded by a multiyear award from the U.S. Department of Energy. and of the Center of Excellence in Genomic Science (CEGS) at Harvard, funded by a P50-type award from the National Human Genome Research Institute (NHGRI), a part of the National Institutes of Health.NHGRI, 2015, Active Centers of Excellence in Genomic Science Awards: Causal Transcriptional Consequences of Human Genetic Variation (P50 HG005550, George M. Church, Harvard University), see . Retrieved 26 February 2015. He co- founded Veritas Genetics and its European and Latin American subsidiary, Veritas Intercontinental, with the idea of bringing the benefits of genomic data to millions of people globally. Research Church is known for his professional contributions in the sequencing of genomes and interpreting such data, in synthetic biology and genome engineering, and in an emerging area of neuroscience that proposes to map brain activity and establish a "functional connectome." Among these, Church is known for pioneering the specialized fields of personal genomics and synthetic biology. He has co-founded commercial concerns spanning these areas, and others from green and natural products chemistry to infectious agent testing and fuel production, including Knome, LS9, and Joule Unlimited (respectively, human genomics, green chemistry, and solar fuel companies). , according to Google Scholar, his most cited research has been published in peer reviewed scientific journals including PNAS, Nature Genetics, nature reviews genetics the Intelligent Systems for Molecular Biology (ISMB) conference, Nature Biotechnology, Science, the Journal of Molecular Biology, the Pacific Symposium on Biocomputing (PSB) conference, the Journal of Bacteriology, Nature, Nature Methods, Genome Biology, Bioinformatics, PLOS Genetics, and Nucleic Acids Research. Genome sequencing and interpretation technologies With Walter Gilbert, Church published the first direct genomic sequencing method in 1984. Described in that publication were the cyclic application of fluids to a solid phase alternating with imaging, plus avoidance of bacterial cloning, strategies that are still used in current dominant Next-Generation Sequencing technologies. These technologies began to affect genome-scale sequencing in 2005. Church also helped initiate the Human Genome Project in 1984. He invented the broadly applied concepts of molecular multiplexing and barcode tags. Technology transfer from his Harvard laboratory of automated sequencing and software to Genome Therapeutics Corp. resulted in the first bacterial genome sequence and first commercial genome (the human pathogen Helicobacter pylori) in 1994. Church was also co-inventor of nanopore sequencing in 1995, which are now commercially available (e.g. Oxford Nanopore Technologies), but not in the form embodied in Church's contribution to the original patents. To aid in the interpretation and sharing of genomes, Church, in 2005, initiated the Personal Genome Project (PGP), which provides the world's only open-access human genome and trait data sets. Eight trios (mother, father, and child) from the Personal Genome Project are in the process of being chosen to act as the primary genome standards (Reference Materials) for the NIST+FDA genomeinabottle.org program. To further advance personal genomics and sharing of genomic data, in 2018 Church co-founded Nebula Genomics, a company that uses blockchain and privacy-preserving computing to make genomic data available to medical researchers, while maintaining privacy. In February 2020, Nebula Genomics started offering personal genome sequencing for $299. Synthetic biology and genome engineering He has co-developed "genome engineering" technologies since 1997 via either general homologous recombination (recA and lambda-red) or via sequence-specific nucleases. Since 2004, his team has developed use of DNA array (aka DNA chip) synthesizers for combinatorial libraries and assembling large genome segments. He co-developed Multiplex Automated Genome Engineering (MAGE) and optimized CRISPR/Cas9 discovered by Jennifer Doudna and Emanuelle Charpentier for engineering a variety of genomes ranging from yeast to human. His laboratory's use of CRISPR in human induced pluripotent stem cells (hiPS) is the latest contender for precise gene therapy. His team is the first to tackle a genome-scale change in the genetic code. This was done in a 4.7 million basepair genome of an industrially useful microbe (E. coli) with the goal of making a safer and more productive strain; this strain uses non-proteinogenic amino acids in proteins and is metabolically and genetically isolated from other species. He has co- invented several uses for DNA, including detectors for dark matter – Weakly interacting massive particles (WIMPs), anti-cancer "nano-robots", and strategies for digital data storage that are over a million times denser than conventional disk drives. Together with polymerase, DNA can be used to sense and store variation in photons, nucleotides, or ions. The BRAIN initiative He was part of a team of six who, in a 2012 scientific commentary, proposed a Brain Activity Map, later named BRAIN Initiative (Brain Research through Advancing Innovative Neurotechnologies). They outlined specific experimental techniques that might be used to achieve what they termed a "functional connectome", as well as new technologies that will have to be developed in the course of the project, including wireless, minimally invasive methods to detect and manipulate neuronal activity, either utilizing microelectronics or synthetic biology. In one such proposed method, enzymatically produced DNA would serve as a "ticker tape record" of neuronal activity. Woolly mammoth cloning In March 2015, Church and his genetics research team at Harvard successfully copied some woolly mammoth genes into the genome of an Asian elephant. Using the CRISPR DNA editing technique, his group spliced genetic segments from frozen mammoth specimens, including genes from the ears, subcutaneous fat, and hair attributes, into the DNA of skin cells from a modern elephant. This marked the first time that woolly mammoth genes had been functionally active since the species became extinct. Their work has not been subject to peer review, however. Church stated that "Just making a DNA change isn't that meaningful. We want to read out the phenotypes." To do that, the team plans to perform further tests to get the hybrid cells into becoming specialized tissues, and from there attempting to turn the hybrid elephant/mammoth skin cells into hybrid embryos that can be grown in artificial wombs. Technology transfer and translational impact Church has co-founded 22 companies, including Veritas Genetics (human genomics, 2014, with Mirza Cifric, Preston Estep, Yining Zhao, Joe Thakuria), Warp Drive Bio (natural products, 2011, with Greg Verdine and James Wells), Alacris (cancer systems therapeutics, 2010, with Hans Lehrach, Bernhard Herrmann, and Shahid Imran), Knome (human genomics, 2007, with Jorge Conde and Sundar Subramaniam), Pathogenica (microbe and viral NGS diagnostics, 2009, with Yemi Adesokan), AbVitro (immunomes, 2010, with Francois Vigneault), Gen9 Bio (synthetic biology, 2009, with Joseph Jacobson and Drew Endy), EnEvolv (Genome Engineering), Joule Unlimited (SolarFuels, 2007, with Noubar Afeyan and David Berry), and LS9 (green chemistry, 2005, with Chris Somerville, Jay Keasling, Vinod Khosla, Noubar Afeyan, and David Berry) He has participated in technology development, licensing patents and advising most of the Next-Generation Sequencing companies, including Complete Genomics, Life Technologies, Illumina, Danaher Corporation, Roche Diagnostics, Pacific Biosciences, Genia, and Nabsys. He was on the Scientific Advisory Board of Cambrian Genomics Support of open consent Church spearheaded the concept and implementation of open access sequencing hardware and shareable human medical data. He has noted the potential for re-identification of human research participants and the tendency for consent forms to be opaque – proposing an alternative "open consent" mechanism. He has participated in the Presidential Commission for the Study of Bioethical Issues, cautioning about the risk of synthetic DNA and proposing risk-reduction via licensing and surveillance. His laboratory has a major bio-safety engineering focus. TED 2010, picture by Steve Jurvetson. Support of open education He has been an early advocate of online, open education since 2002. He is advisor to the Personal Genetics Education Project and has spent a day teaching at The Jemicy School. He has championed citizen science, especially in the fields of synthetic biology and personal genomics. Since 2008, his team has been hosting an annual Genomes, Environments and Traits (GET) Conference with free online videos. Controversies Harvard and MIT geneticist George Church lists the nonprofit Jeffrey Epstein VI Foundation, a private foundation established by convicted sex offender Jeffrey Epstein, as a source of funding. According to George Church's Harvard website, this funding started in 2005 and continued to 2007. Church's Jeffrey Epstein VI Foundation affiliation is listed as for cutting edge science & education. Church met with Epstein many times after Epstein's 2008 conviction. In his 2019 apology for "poor awareness" of Epstein's sex offender status, Church said he had "nerd tunnel vision" and articles on Epstein's crimes were unclear, placing responsibility on vetting donors on the development office. Controversy found Church in early 2013, in response to his spoken speculations as to what was required to engineer the birth of a Neanderthal. In response to a question from Der Spiegel, Church speculated that it could be technically possible to make a Neanderthal by reconstructing the DNA of a Neanderthal and modifying living human cells accordingly. Church pointed out that he was not working on such a project. Popular science In his science and popular efforts, Church has also promoted open access genome sequencing and shareable human medical data, as well as online, open education and citizen science. Church authored the 2012 NewScientist "top science book," Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves with Ed Regis. He has participated in news interviews and videos including at TED, TEDx,TEDx, 2012, "TEDxCambridge: George Church on genomics and human diversity," 21 March 2012, see . Retrieved 4 March 2014.TEDx, 2013, "Hybridizing with extinct species: George Church at TEDxDeExtinction," 8 May 2013, see . Retrieved 4 March 2014.TEDx, 2013, "DNA [as detectors], George-Church-at-TEDxCERN," 24 May 2013, see . Retrieved 4 March 2014. and TEDMED venues, at PBS's Charlie Rose,charlierose.com, 2009, "Personalized Medicine, …GUESTS/AFFILIATIONS: ...Steven Pinker, Harvard University, George Church, Harvard Medical School, Personal Genome Project," air date 19 June 2009, see and . Retrieved 4 March 2015. Faces of America, and NOVA, as well as at PopSci, EG, and The Colbert Report. He is a regular contributor to Edge.org publications and videos and is a member of the Xconomists, an ad hoc team of editorial advisors for the tech news and media company, Xconomy. Awards and honors Church has received accolades including election to the National Academy of Sciences (in 2011), and the National Academy of Engineering (in 2012). He received the American Society for Microbiology Promega Biotechnology Research Award and the heptannual Bower Award and Prize for Achievement in Science of the Franklin Institute. He authored the NewScientist "top science book," Regenesis (on synthetic biology) with Ed Regis. Church is a regular contributor to Edge.org and has appeared widely in the media, including TED venues, NOVA, Faces of America, Charlie Rose on PBS, The Colbert Report, and Xconomy. Other honors include the Triennial International Steven Hoogendijk Award in 2010 and the Scientific American Top 50 twice (for "Designing artificial life" in 2005 and "The $1000 genome" in 2006). Newsweek picked Church for their 2008 "Power of Ideas" recognition in the category of Medicine (for the Personal Genome Project). In September 2010, Dr Church was honored for his work in genetics with the Mass High Tech All-Star Award. He is a member of the Research Advisory Board of SENS Research Foundation. Personal life Church is married to fellow Harvard Medical School faculty member in genetics Ting Wu. Church has been outspoken in his support of following a vegan lifestyle, for reasons concerned with health, and with environmental and moral issues. When asked about his dietary choice, Church replied, "I've been vegan off-and-on since 1974 when I was inspired by participating in an MIT nutritional study, and quite strictly since 2004." He goes on to elaborate 4 reasons: > "medical (cholesterol in fish & dairy), energy conservation (up to 20-fold > impact), cruelty ("organic" animals are deprived of medicines that humans > use), and risks of spreading pathogens (not just the flu)… [noting that] > veganism is an issue for which personal and global love of life, health and > wealth align. It's a pity to lose parts of our humanity and planet just due > to a lack of recipes." George identifies as a sentientist. Sentientism is a naturalistic worldview that grants moral consideration to all sentient beings. In the context of the Personal Genome Project, journalists at Forbes and Wired have noted Church's openness about his health issues, including dyslexia, narcolepsy, and high cholesterol (one of the motivations for his vegan diet). Further reading Alex Salton, 2009, "Geneticist George Church '72 Sought Independence at PA," The Phillipian, 17 April 2009, see . Retrieved 2 March 2015. * David Ewing Duncan, 2010, "On a Mission to Sequence the Genomes of 100,000 People: The geneticist George Church advises or licenses technology to most companies involved in sequencing, The New York Times, 7 June 2010, see . Retrieved 26 February 2015. * Jeffrey M. Perkel, 2011, "Charting the Course: Three gene jockeys share their thoughts on past and future tools of the trade," in The Scientist (online), 1 October 2011. see . Retrieved 26 February 2015. * Heidi Legg, 2014, "Harvard Professor George Church and the future of genomics," at BetaBoston, a Boston Globe site (online), 25 December 2014, see . Retrieved 2 March 2015. * Peter Miller, 2015, "News, The Innovators Project: George Church, The Future Without Limits," National Geographic (online), see . Retrieved 26 February 2015. * Matthew Allen, 2015, "Artificial Natures (interview with George Church)," Harvard Design Magazine (online), see . Retrieved 10 February 2016. ReferencesExternal links * The future of genetic codes and BRAIN codes (Dr. Church's seminar at the NIH on 8 February 2017) Category:20th-century American biologists Category:21st-century American biologists Category:American biochemists Category:American geneticists Category:Human geneticists Category:Synthetic biologists Category:Systems biologists Category:Life extensionists Category:Howard Hughes Medical Investigators Category:Harvard Medical School faculty Category:Duke University alumni Category:Harvard Medical School alumni Category:Phillips Academy alumni Category:Members of the United States National Academy of Engineering Category:Members of the United States National Academy of Sciences Category:American transhumanists Category:Veganism activists Category:People with narcolepsy Category:People with dyslexia Category:People from Boston Category:People from Tampa, Florida Category:1954 births Category:Living people Category:Sentientists "