Appearance
🎉 your library🥳
"Gedocarnil (INN) is an anxiolytic of the β-carboline class related to abecarnil. It is registered as an anxiolytic under the WHO's ATC classification system; however, there are no trade names associated with it and it does not appear to have ever been marketed. See also * Nonbenzodiazepine References Category:Anxiolytics Category:Beta-Carbolines Category:Chloroarenes Category:Carboxylate esters Category:Ethers Category:Phenol ethers Category:GABAA receptor positive allosteric modulators "
"Mephenoxalone (trade names Dorsiflex, Moderamin, Control-OM) is a muscle relaxant and mild anxiolytic.MIMS: Mephenoxalone It inhibits neuron transmission, relaxing skeletal muscles by inhibiting the reflex arc. As the effect of muscle relaxation, mephenoxalone affects mental condition, and is also a treatment for nervousness and anxiety. See also * Chlorphenesin * Guaifenesin * Mephenesin * Metaxalone * Methocarbamol References Category:Carbamates Category:Drugs with unknown mechanisms of action Category:Oxazolidines Category:Phenol ethers "
"Tandospirone (brand name Sediel) is an anxiolytic and antidepressant drug used in China and Japan, where it is marketed by Dainippon Sumitomo Pharma. It is a member of the azapirone class of drugs and is closely related to other azapirones like buspirone and gepirone. Medical uses=Anxiety and depression Tandospirone is most commonly used as a treatment for anxiety and depressive disorders, such as generalised anxiety disorder and dysthymia respectively. For both indications it usually takes a couple of weeks for therapeutic effects to begin to be seen, although at higher doses more rapid anxiolytic responses have been seen. It has also been used successfully as a treatment for bruxism. Other uses Tandospirone has also been tried, successfully, as an adjunctive treatment for cognitive symptoms in schizophrenic individuals. Side effects Common adverse effects include: * Dizziness * Drowsiness * Insomnia * Headache * Gastrointestinal disorders * Dry mouth * Negative influence on explicit memory function Adverse effects with unknown frequency include: * Hypotension (low blood pressure) * Dysphoria * Tachycardia * Malaise * Psychomotor impairment It is not believed to be addictive but it is known to produce mild withdrawal effects (e.g. anorexia) after abrupt discontinuation. Pharmacology Tandospirone acts as a potent and selective 5-HT1A receptor partial agonist, with a Ki affinity value of 27 ± 5 nM and approximately 55 to 85% intrinsic activity. It has weak and clinically negligible affinity for the 5-HT2A (1,300 ± 200), 5-HT2C (2,600 ± 60), α1-adrenergic (1,600 ± 80), α2-adrenergic (1,900 ± 400), D1 (41,000 ± 10,000), and D2 (1,700 ± 300) receptors, and is essentially inactive at the 5-HT1B, 5-HT1D, β-adrenergic, and muscarinic acetylcholine receptors, serotonin transporter, and benzodiazepine allosteric site of the GABAA receptor (all of which are > 100,000). There is evidence of tandospirone having low but significant antagonistic activity at the α2-adrenergic receptor through its active metabolite 1-(2-pyrimidinyl)piperazine (1-PP). Research In February 2018, a study was conducted by researchers at the Queensland University of Technology and published in the journal Scientific Reports. Researchers found that tandospirone helped reverse brain deficits caused by chronic alcohol exposure in mice. The study was the first of its kind and brought interest in the drug for possible treatment of alcohol withdrawal symptoms. Society and culture=Name Tandospirone has also been known as metanopirone. References Category:5-HT1A agonists Category:Antidepressants Category:Anxiolytics Category:Azapirones Category:Imides Category:Piperazines Category:Aminopyrimidines Category:Cyclopentanes "